Topinate (Skin) (30 Gm)
INDICATORSPregnancy:C Lactation:L4 Lab:NA Food:NA
Atopic eczema. Allergic contact dermatitis. Lichen simplex. Primary irritant dermatitis. Seborrheic dermatitis. Psoriasis of face, flexures. Varicose eczema. Cystic acne. Alopecia areata. Discoid LE. Hypertrophied scars, keloids. Lichen planus. Nail disorders. Psoriasis of palm, sole, elbow, knee. A combination of steroid with proper antibiotic cover may also be used for: Impetigo, furunculosis, secondary infected dermatoses, napkin rash, otitis externa, intertriginous eruptions.
Perioral dermatitis, striae esp in flexures. Dermal and epidermal atrophy esp on the face, steroid purpura.
No data regarding the interactions of Clobetasol (Propionate) was found.
MECHANISM OF ACTION
The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Initially, however, clobetasol, like other corticosteroids, bind to the glucocorticoid receptor, which complexes, enteres the cell nucleus and modifies genetic transcription (transrepression/transactivation).
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