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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Atopic eczema. Allergic contact dermatitis. Lichen simplex. Primary irritant dermatitis. Seborrheic dermatitis. Psoriasis of face, flexures. Varicose eczema. Cystic acne. Alopecia areata. Discoid LE. Hypertrophied scars, keloids. Lichen planus. Nail disorders. Psoriasis of palm, sole, elbow, knee. A combination of steroid with proper antibiotic cover may also be used for: Impetigo, furunculosis, secondary infected dermatoses, napkin rash, otitis externa, intertriginous eruptions.
Side Effects: Perioral dermatitis, striae esp in flexures. Dermal and epidermal atrophy esp on the face, steroid purpura.
Drug Interaction: No data regarding the interactions of Clobetasol (Propionate) was found.
Mechanism Of Action: The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Initially, however, clobetasol, like other corticosteroids, bind to the glucocorticoid receptor, which complexes, enteres the cell nucleus and modifies genetic transcription (transrepression/transactivation).
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Showing 5 of 24