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Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Respiratory tract infections. Uncomplicated gonorrhoea. Otitis media. Meningitis, Prophylaxis of surgical infections. Susceptible infections.
Side Effects: Pseudomembranous colitis, urticaria, thrombocytopenia, hemolytic anemia, skin rashes, serum sickness, hypersensitivity reactions, nausea, vomiting, diarrhea, urticaria, pruritus, jaundice, skin rash, pseudomembranous colitis, elevation of liver enzymes, drug fever.
Drug Interaction: Cefuroxime is known to interact with other drugs like probenecid.
Mechanism Of Action: Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins, it is possible that cefuroxime interferes with an autolysin inhibitor.
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