Select to order medicines [Delhi/NCR /Bangalore /Chennai /Bhubaneswar /Mumbai]
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Asthma, Congestive heart failure, Degradation of pancreatic enzyme suppliments, Edema, Heart failure, Hypertension, Long-term treatment of healed reflux oesophagitis, Oedema, Oliguria, Oliguria due to renal failure, Oliguria due to renal failure, Pulmonary edema
Side Effects: Photosensitivity, Skin rashes, Ototoxicity, Nephrocalcinosis, Hyponatremia, Urinary retention, Dizziness, Blurred vision, Hypokalemia, Cardiac arrhythmias, CHO intolerance, Hypomagnesemia, Hyperosmolar non-ketotic precoma, deafness, Hypocalcemic tetany, Ototoxicity, Hypochloremic alkalosis.
Drug Interaction: Furosemide is known to interact with other drugs like Aliskiren, Amikacin (Sulphate), Arbekacin, Caffeine, Calcium Gluconate, Captopril, Carbamazepine, Cefaclor (Monohydrate), Cefazolin, Cefotaxime, Ceftizoxime (Na).
Mechanism Of Action: Furosemide inhibits reabsorption of Na and chloride mainly in the medullary portion of the ascending Loop of Henle. Excretion of potassium and ammonia is also increased while uric acid excretion is reduced. It increases plasma-renin levels and secondary hyperaldosteronism may result.
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: All forms of epilepsy, Congestive heart failure, Electrolyte disorder, For prophylaxis in pregnancy, Hirsutism, Hyperaldoesteronism, Hypertension, Myoclonus, Nephrotic syndrome, Oedema, Oedema and ascites in cirrhosis of the liver, Parkinson's disease; drug-induced extrapyramidal symptoms, Primary hyperaldosteronism, Tobacco amblyopia and leber's optic atrophy.
Side Effects: Diarrhea, Drowsiness, Dizziness, Mental confusion.
Drug Interaction: Sodium excretion effect may be inhibited by aspirin. May reduce ulcer-healing properties of carbenoxolone.
Mechanism Of Action: Spironolactone acts on the distal renal tubules as a competitive antagonist of aldosterone. It increases the excretion of sodium chloride and water while conserving potassium and hydrogen ions.