Zerodol Th 8
INDICATORSPregnancy:D Lactation:L4 Lab:NA Food:NA
Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis.
Diarrhoea, nausea, dyspepsia, abdominal pain, dizziness, rashes
May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants
MECHANISM OF ACTION
Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
INDICATORSPregnancy:C Lactation:L5 Lab:NA Food:NA
Nausea, stomach upset, skin rash, acute toxicity.
Drug interactions associated with Acepol T are similar to those observed with other NSAIDs. Aceclofenac may increase plasma concentrations of lithium, digoxin and methotrexate, increase the activity of anticoagulants, inhibit the activity of diuretics, enhance cyclosporin nephrotoxicity and precipitate convulsions when co-administered with quinolone antibiotics. When concomitant administration with potassium sparing diuretics is employed, serum potassium should be monitored. Furthermore, hypo or hyperglycaemia may result from the concomitant administration of aceclofenac and antidiabetic drugs, although this is rare. The co-administration of aceclofenac with other NSAIDs or corticosteroids may result in increased frequency of side effects. Caution should be exercised if NSAIDs and methotrexate are administered within 2-4 hours of each other, since NSAIDs may increase methotrexate plasma levels, resulting in increased toxicity. Potential hepatotoxicity of Paracetamol may be increased by large doses or long-term administration of barbiturates, carbamazepine, hydantoins, isoniazid, rifampin and sulfinpyrazone.
MECHANISM OF ACTION
This medication is a muscle relaxant, for the relief of discomfort associated with acute, painful musculoskeletal conditions.
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