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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Aerobic and anaerobic infections.
Side Effects: Pseudomembranous colitis, thrombocytopenia, angioneurotic edema, serum sickness, granulocytopenia, leucopenia, neutropenia, nausea, diarrhea, fever, tinnitus, skin rashes, urticaria, vertigo, stomatitis, esophagitis, perianal irritation.
Drug Interaction: Lincomycin is known to interact with other drugs like alcuronium (Cl), atracurium (Besylate), bamifylline, clindamycin, distigmine (Br), erythromycin, kaolin, rocuronium (Br). These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Lincomycin inhibits protein synthesis in susceptible bacteria by binding to the 50 S subunits of bacterial ribosomes and preventing peptide bond formation upon transcription. It is usually considered bacteriostatic, but may be bactericidal in high concentrations or when used against highly susceptible organisms.
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Showing 5 of 49