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There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Replacement therapy: Adrenal insufficiency. Adrenogenital syndrome. Nonendocrine diseases: Rheumatoid arthirits. Osteoarthritis, Acute gouty arthirits. Collagen diseases e.g. systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, nephritic syndrome, glomerulonephritis and related diseases. Severe allergic reactions e.g. anaphylaxis, angioneurotic edema, urticaria and serum sickness and related diseases. Autoimmune diseases e.g. haemolytic anaemia, idiopathic thrombocytopenic purpura, active chronic hepatitis and related diseases. Other lung diseases e.g. pulmonary edema, accelerate lung maturation and surfactant production in the foetus and prevent respiratory distress syndrome at birth. Infective diseases e.g. severe forms of tuberculosis, severe lepra reaction, certain forms of bacterial meningitis and Pneumocystis carinii pneumonia with hypoxia in AIDS patients along with proper antibiotic cover. Eye diseases e.g. inflammatory ocular diseases, allergic conjunctivitis, iritis, iridocyclitis, keratitis, retinitis, optic neuritis, uveitis. Skin diseases e.g. eczematous skin diseases. Pemphigus vulgaris, exfoliative dermatitis, Stevens Johnson syndrome. Intestinal diseases e.g. ulcerative colitis, Crohns disease, coeliac disease are chronic inflammatory intestinal diseases. Cerebral edema. Malignancies e.g. Acute lymphatic leukaemia, Hodgkins and other lymphomas. Hormone responsive breast carcinoma. Organ transplantation and skin allograft. Septic shock. Thyroid storm.
Side Effects: Atrophy, steroid purpura, steroid purpura, skin fragility, angioedema, perioral dermatitis, vertigo, headache, diarrhea, fever, anxiety, constipation, abdominal pain, sweating, erythema, hypotension, arthralgia, acne, hypersensitivity reactions, menstrual irregularity, cataract, hypertrichosis, pigmentation, superficial blood vessels dilatation, local hypopigmentation.
Drug Interaction: Betamethasone is known to interact with other drugs like amphotericin B, carbamazepine, lofexidine, metyrosine, oxandrolone, perindopril, phenytoin (Na), rifampicin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibits arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes.
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Showing 5 of 10