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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Acute sinusitis. Acute exacerbation of chronic bronchitis. Community acquired pneumonia. Urinary tract infections including pyelonephritis. Skin and soft tissue infections.
Side Effects: Stevens johnson syndrome, epidermal necrolysis, tendon rupture, QT prolongation, flatulence, dizziness, diarrhea, anxiety, restlessness, constipation, abdominal pain, confusion, pruritus, hallucination, dyspepsia.
Drug Interaction: Levofloxacin is known to interact with other drugs like aluminium hydroxide and oxide, cyclosporin A, fenbufen, probenecid, theophylline, warfarin (Na). These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.
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