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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Mild to moderate ulcerative colitis and maintenance of remission.
Side Effects: Bronchospasm, nephrotic syndrome, blood dyscrasias, myocarditis, pericarditis, headache, nausea, vomiting, diarrhea, fever, rashes, hair loss, chest pain, leukopenia.
Drug Interaction: Mesalazine is known to interact with other drugs like lactulose. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes and hydroxyeicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
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