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Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: secondary amenorrhea
Side Effects: Hepatitis, cataract, cholestatic jaundice, optic neuritis, hyperglycemia, hypertension, mental disturbances, retinal thrombosis, dizziness, fatigue, anorexia, anxiety, abdominal pain, rashes, weight Loss, depression, weight gain, elevation of liver enzymes, nausea and vomiting, edema, acne, hirsutism, breast discomfort.
Drug Interaction: Norethisterone is known to interact with other drugs like cyclosporin A, estrogens conjugated, griseofulvin, phenytoin (Na), rifampicin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Norethisterone converts the endometrium from the proliferative to the secretory phase. It may also have some estrogenic, anabolic and androgenic activities. The contraceptive effects are due to negative feedback inhibition of pituitary gonadotropin, whereby it prevents ovulation.
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