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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Uro-genital infections. Typhoid fever. Acute bacterial gastroenteritis. Chronic bacterial prostatitis. Gonorrhoea, Prophylaxis of sepsis in neutropenic patients. Eye and ear infections.
Side Effects: Hepatitis, hemolytic anemia, seizures, exfoliative dermatitis, interstitial nephritis, headache, nausea, vomiting, diarrhea, fever, constipation, insomnia, dry mouth, rashes, GI symptoms, depression, arthralgia.
Drug Interaction: Norfloxacin is known to interact with other drugs like aluminium hydroxide and oxide, caffeine, cyclosporin A, probenecid, theophylline, warfarin (Na), Zinc Sulphate.
Mechanism Of Action: Norfloxacin inhibits the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacterias. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomonal activity
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