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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Genito urinary, respiratory, gastro intestinal. skin and soft tissue infections. Peritonitis, Gonorrhoea. Typhoid fever, Multi drug resistant tuberculosis. Acute and sub-acute eye and ear infections.
Side Effects: Sinus tachycardia, hallucinations, stevens johnson syndrome, seizures, tendon rupture, dizziness, headache, nausea, vomiting, diarrhea, insomnia, abdominal pain, pruritus, photosensitivity.
Drug Interaction: Ofloxacin is known to interact with other drugs like aluminium hydroxide and oxide, didanosine, iron Salts, pentostatin, probenecid, procainamide (HCl), sucralfate, theophylline. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.
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