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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Diabetes mellitus type-II, softening and dilatation of cervix before mechanical cervical dilatation.
Side Effects: Jaundice, headache, myalgia, pharyngitis, sinusitis.
Drug Interaction: Pioglitazone is known to interact with other drugs like adrenaline, baclofen, budesonide, carbamazepine, clozapine, diazoxide, gemfibrozil, ginkgo biloba extract, ginseng extract, lovastatin, octreotide (Acetate), olanzapine, phenobarbitone, phenytoin (Na), rifabutin, risperidone, sotalol (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Pioglitazone acts as an agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors increases the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. Pioglitazone both enhances tissue sensitivity to insulin and reduces hepatic gluconeogenesis.
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