Revulant 500 Tab
SALT INFORMATIONRanolazine(500 mg)
INDICATORSPregnancy:C Lactation:L4 Lab:NA Food:NA
Chronic angina pectoris, non ST elevation acute coronary syndrome and acute myocardial infarction.
Nausea, Vomiting, Confusion, Dizziness, Paresthesia, Syncope.
MECHANISM OF ACTION
The mechanism of action of ranolazine is unknown. It does not increase the rate-pressure product, a measure of myocardial work, at maximal exercise. In vitro studies suggest that ranolazine is a P-gp inhibitor. Ranolazine is believed to have its effects via altering the trans-cellular late sodium current. It is by altering the intracellular sodium level that ranolazine affects the sodium-dependent calcium channels during myocardial ischemia. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia.
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