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Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Gram negative folliculitis, keratinization disorders, mild acne in patients with dysmorphohobia, rosacea, severe acne.
Side Effects: Thrombocytopenia, hepatitis, myalgia, hypercholesterolemia, alopecia, abdominal pain, blurred vision, arthralgia, cheilitis, nasal bleeding, skin sepsis, desquamation, facial dermatitis, epistaxis.
Drug Interaction: Isotretinoin is known to interact with other drugs like carbamazepine, resorcinol, retinol (Vitamin A), sodium thiosulphate, tetracycline (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Isotretinoin noticeably reduces the production of sebum and shrinks the sebaceous glands. It stabilises keratinization and prevents comedones from forming. It also reduces inflammation in moderate-severe inflammatory acne. The exact mechanism of action is unknown, however it is known that it alters DNA transcription.
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Showing 5 of 36