Select to order medicines [Delhi/NCR /Bangalore /Chennai /Bhubaneswar /Hyderabad/Pune & Mumbai region.]
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Treatment of coronary artery disease, treatment of chronic heart failure.
Side Effects: Blurred vision, bradycardia, ventricular extrasystoles, atrioventricular first degree block, headache, dizziness, myocardial infarction, ventricular tachycardia, vertigo, nausea, constipation, diarrhoea, asthenia, fatigue, elevated creatinine in blood, ECG prolonged QT interval, hyperuricaemia, muscle cramps, syncope, dyspnoea, hypotension, angioedema, rash.
Drug Interaction: Ivabradine is known to interact with other drugs like ketoconazole, macrolide antibiotics, cyclosporin, gestodene, anti-retroviral drugs, verapamil. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Ivabradine acts on the If (f is for "funny") ion current, which is highly expressed in the sinoatrial node. If is a mixed Na+ĚK+ inward current activated by hyperpolarization and modulated by the autonomic nervous system. It is one of the most important ionic currents for regulating pacemaker activity in the sinoatrial (SA) node. Ivabradine selectively inhibits the pacemaker If current in a dose-dependent manner. Blocking this channel reduces cardiac pacemaker activity, slowing the heart rate and allowing more time for blood to flow to the myocardium.
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Showing 5 of 10