Deslan (10 Mg)
SALT INFORMATIONLabetalol(5 mg)
INDICATORSPregnancy:C Lactation:L3 Lab:NA Food:NA
Angina, constipation and bowel evacuation, drying secretions, hypertension, hypertension following myocardial infarction, hypertensive emergencies, hypotension induction with anesthesia.
Bronchospasm, hepatic necrosis, systemic lupus erythematosus, myopathy, urinary retention, dizziness, heart failure, fatigue, headache, nausea, vomiting, diarrhea, nasal stiffiness, weight gain, nightmares, chest pain, shortening of breath.
Labetalol is known to interact with other drugs like alprazolam, atropine (Sulphate), cimetidine (HCl), diltiazem (HCl), halothane, imipramine (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Labetalol combines both selective, competitive, alpha-1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. Labetalol competitively block adrenergic stimulation of ?-receptors within the myocardium (?1-receptors) and within bronchial and vascular smooth muscle (?2-receptors), and ?1-receptors within vascular smooth muscle. This causes a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined ?- and ?-adrenergic blocking activity.
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