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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Angina, constipation and bowel evacuation, drying secretions, hypertension, hypertension following myocardial infarction, hypertensive emergencies, hypotension induction with anesthesia.
Side Effects: Bronchospasm, hepatic necrosis, systemic lupus erythematosus, myopathy, urinary retention, dizziness, heart failure, fatigue, headache, nausea, vomiting, diarrhea, nasal stiffiness, weight gain, nightmares, chest pain, shortening of breath.
Drug Interaction: Labetalol is known to interact with other drugs like alprazolam, atropine (Sulphate), cimetidine (HCl), diltiazem (HCl), halothane, imipramine (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Labetalol combines both selective, competitive, alpha-1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. Labetalol competitively block adrenergic stimulation of ?-receptors within the myocardium (?1-receptors) and within bronchial and vascular smooth muscle (?2-receptors), and ?1-receptors within vascular smooth muscle. This causes a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined ?- and ?-adrenergic blocking activity.
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