Select to order medicines [Delhi/NCR /Bangalore /Chennai /Bhubaneswar /Mumbai]
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Adjunctive treatment of partial seizures, oedema, seizures, seizures associated with lennox gastaut syndrome.
Side Effects: Dizziness, ataxia, nervousness, confusion, pharyngitis, depression, edema, hot flushes, somnolence, chest pain, backache, rigors, xerostomia, speech problems.
Drug Interaction: Topiramate is known to interact with other drugs like carbamazepine, digoxin, fosphenytoin, phenytoin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Topiramate blocks the action potentials elicited repetitively by a sustained depolarization of the neurons in a time dependent manner. Topiramate also augments the activity of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABAA receptor (controls an integral chloride channel), indicating a possible mechanism through potentiation of the activity of GABA.
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Showing 5 of 13