Select to order medicines [Delhi/NCR /Bangalore /Chennai /Bhubaneswar /Hyderabad/Pune & Mumbai region.]
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Cardiac arrhythmia, coronary artery spasm, hypertension, migraine, moderate to severe reflux oesophagitis, myocardial infarction, oesophageal motility disorders, pulmonary hypertension, raynaud's phenomenon.
Side Effects: Paralytic ileus, pedal edema, impaired left vntricular function, sinus arrest, atrioventricular conduction disturbances, dizziness, headache, drowsiness, constipation, insomnia, peripheral edema, bradycardia, GI upset, hypotension, flushing.
Drug Interaction: Diltiazem is known to interact with other drugs like acebutolol, alprazolam, amiodarone (HCl), amobarbital, atenolol, betaxolol (HCl), bisoprolol (Fumarate), buspirone (HCl), carbamazepine, carteolol (HCl), cimetidine (HCl), cyclosporin A, digoxin, disopyramide, enflurane, fosphenytoin, human insulin, imipramine (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Diltiazem inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.
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