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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Enteric fever (Typhoid and Para typhoid). H.Influenzae meningitis. Anaerobic infections, intraocular infections, urinary tract infections, conjunctivitis, external ear infections. Corneal ulcer, bacterial conjunctivitis, trachoma, ocular infections. Otitis externa, chronic otitis media. Pre and post antral or mastoid surgery.
Side Effects: Encephalopathy, pseudomembranous colitis, anemia, urticaria, anemia, thrombocytopenia, hepatitis, ototoxicity, peripheral neuropathy, optic neuritis, hemolytic reactions, interstitial nephritis, headache, nausea, vomiting, maculopapular rash, stomatitis, confusion, pruritus, depression, glossitis, delirium, transient stinging.
Drug Interaction: Chloramphenicol is known to interact with other drugs like amoxicillin, ampicillin, ascorbic acid, azlocillin (Na), bacampicillin, benzathine penicillin, carbenicillin (Na), chlorpropamide, chymotrypsin, cimetidine (HCl), ciprofloxacin, cloxacillin, clozapine, colistin (Sulphate & Sulphomethate Na), cyanocobalamin, cyclophosphamide, dicloxacillin (Na), ethinyloestradiol, floxacillin (Na), fosphenytoin, estodene, glibornuride, gliquidone, hydroxocobalamin, ichthammol, iron dextran, iron salts, iron sorbitol, mecillinam, mecobalamin, nafcillin, oxacillin, paracetamol, phenobarbitone, phenytoin (Na), piperacillin (Na),pivmecillinam (HCl), primidone, procaine penicillin, promethazine (HCl),rifampicin, sulfapyridine, tolbutamide, warfarin (Na).
Mechanism Of Action: Chloramphenicol is lipid-soluble, allowing it to diffuse through the bacterial cell membrane. It then reversibly binds to the L16 protein of the 50S subunit of bacterial ribosomes, where transfer of amino acids to growing peptide chains is prevented (perhaps by suppression of peptidyl transferase activity), thus inhibiting peptide bond formation and subsequent protein synthesis.
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Showing 5 of 12