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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: depression,psychoses
Side Effects: Drowsiness, dizziness, confusion, headache, dry mouth, constipation, blurring of vision.
Drug Interaction: Sedatives, hypnotics, anxiolytics (for sleeping troubles and anxiety, such as zopiclone, diazepam, nitrazepam). Opioid analgesics (for pain, such as codeine, morphine, tramadol)
Mechanism Of Action: Doxepin inhibits serotonin and norepinephrine re-uptake by the presynaptic neuronal membrane increasing its synaptic conc in the CNS.