Clofranil (25 Mg)
SALT INFORMATIONClomipramine(25 mg)
INDICATORSPregnancy:C Lactation:L3 Lab:NA Food:NA
Edogenous depression. Obsessive compulsive neurosis and phobic states.
Parkinsonism, jaundice, seizures, extrapyramidal symptoms, bone marrow depression, hypertension, vomiting, tachycardia, convulsions, coma, drowsiness, ataxia, mydriasis, agitation, restlessness, impaired impulse conduction, headache, drowsiness, fatigue, ataxia, fever, anxiety, palpitation, tremors, abdominal pain, blurred vision, confusion, pruritus, erythema, sedation, photosensitivity, hallucination, weight gain, disorientation, reduced salivation, micturition.
Clomipramine is known to interact with other drugs like adrenaline, alcohol, amiodarone (HCl), antazoline, apraclonidine (HCl), cimetidine (HCl), clonidine (HCl), fluoxetine (HCl), fluvoxamine (Maleate).
MECHANISM OF ACTION
Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. ?1-receptor blockage and ?-down-regulation have been noted and most likely play a role in the short term effects of clomipramine. A blockade of sodium-channels and NDMA-receptors might, as with other tricyclics, account for its effect in chronic pain, in particular the neuropathic type.
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