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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Edogenous depression. Obsessive compulsive neurosis and phobic states.
Side Effects: Parkinsonism, jaundice, seizures, extrapyramidal symptoms, bone marrow depression, hypertension, vomiting, tachycardia, convulsions, coma, drowsiness, ataxia, mydriasis, agitation, restlessness, impaired impulse conduction, headache, drowsiness, fatigue, ataxia, fever, anxiety, palpitation, tremors, abdominal pain, blurred vision, confusion, pruritus, erythema, sedation, photosensitivity, hallucination, weight gain, disorientation, reduced salivation, micturition.
Drug Interaction: Clomipramine is known to interact with other drugs like adrenaline, alcohol, amiodarone (HCl), antazoline, apraclonidine (HCl), cimetidine (HCl), clonidine (HCl), fluoxetine (HCl), fluvoxamine (Maleate).
Mechanism Of Action: Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. ?1-receptor blockage and ?-down-regulation have been noted and most likely play a role in the short term effects of clomipramine. A blockade of sodium-channels and NDMA-receptors might, as with other tricyclics, account for its effect in chronic pain, in particular the neuropathic type.
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