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There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Acne vulgaris, anthrax, breast cancer, chronic lymphocytic leukaemia, genitourinary tract infections, GI infections, heart failure, malaria prophylaxis, opthalmic infections, plasmodium falciparum malaria, pneumonia, respiratory tract infections.
Side Effects: Staining of developing teeth, hypoplasia of enamel, pseudomembranous colitis, anaphylaxis, nausea, anorexia, skin reactions, skin rashes, maculopapular rash, urticaria, vaginitis, photosensitivity, glossitis, stomatitis, hemolytic anemia, dysphagia.
Drug Interaction: Doxycycline is known to interact with other drugs like alcohol, carbamazepine, fosphenytoin, glymidine, iron Salts, magnesium Oxides and hydroxides, phenobarbitone, phenytoin (Na), riboflavin (Vitamin B2), rifampicin, sodium acetate, sodium bicarbonate, sodium picosulphate. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis.
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