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Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Urinary tract infections.
Side Effects: Neuropathy, hemolytic anemia, hepatitis, pulmonary disease, nausea, anorexia, skin reactions, abdominal pain, GI hemorrhage, angioedema, vasculitis, drug fever.
Drug Interaction: Nitrofurantoin is known to interact with other drugs like amphotericin B, ascorbic acid, fosphenytoin, gestodene, magnesium oxides and hydroxides, nalidixic acid, probenecid, propantheline (Br), pyridoxine, sulphinpyrazone. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Nitrofurantoin is activated by bacterial flavoproteins (nitrofuran reductase) to active reduced reactive intermediates that are thought to modulate and damage ribosomal proteins or other macromolecules, especially DNA, causing inhibition of DNA, RNA, protein, and cell wall synthesis. The overall effect is inhibition of bacterial growth or cell death.
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Showing 5 of 16