INDICATORSPregnancy:D Lactation:L3 Lab:NA Food:NA
Mild depression. Panic disorders. Anxiety associated with depression.
Psychological and physical dependence with withdrawal syndrome, fatigue, drowsiness, sedation, ataxia, vertigo, confusion, depression, GI disturbances, changes in salivation, amnesia, jaundice, paradoxical excitation, elevated liver enzyme values; muscle weakness, visual disturbances, headache, slurring of speech and dysarthria, mental changes, incontinence, constipation, hypotension, tachycardia, changes in libido, pain and thrombophlebitis at inj site (IV).
Increased clearance of diazepam when used with phenytoin, carbamazepine and phenobarbital. Reversible deterioration of parkinsonism may occur when given together with levodopa. Combination with lithium may produce hypothermia. May need to reduce dose of narcotics when used concurrently.
MECHANISM OF ACTION
Alprazolam is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant and amnestic properties. It increases neuronal membrane permeability to chloride ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron within the CNS and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.
INDICATORSPregnancy:D Lactation:L5 Lab:NA Food:NA
Depression,Obsessive compulsive disorder,Panic disorder,Premenstrual dysphoric disorder.
Dizziness, headache, fatigue, nausea, diarrhea, palpitation, insomnia, somnolence, xerostomia, ejaculatory disturbances.
Sertraline is known to interact with other drugs like alcohol, clozapine, furazolidone, metoprolol (Tartrate), naratriptan, phenelzine, sumatriptan, vilazodone. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Sertraline selectively inhibit the reuptake of serotonin at the presynaptic membrane. This results in an increased synaptic concentration of serotonin in the CNS, which leads to numerous functional changes associated with enhanced serotonergic neurotransmission. These modifications are responsible for the antidepressant action.
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