Istamet (50/500 Mg)

(10 Tablets in Strip)
-14+
Tablet
(1 Strip)
Rs. 22 / Tablet
Rs.308

SALT INFORMATION

Metformin(500MG)

INDICATORS

Pregnancy:X Lactation:L5 Lab:NA Food:NA

TYPICAL USAGE

Diabetes mellitus, Hyperlipoproteinaemia, Insulin dependent diabetes mellitus, Insulin resistance, Non-insulin dependent diabetes mellitus, Obesity.

SIDE EFFECTS

Vasculitis, Pneumonitis, Malabsorption of vit B12, Malabsorpton of folic acid, Megaloblastic anemia, Hypoglycemia.

DRUG INTERACTION

Additive effect with sulphonylureas. Glycaemic control may be affected by diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens.

MECHANISM OF ACTION

The exact mechanism of action of metformin is unclear but it appears to reduce glucose absorption from the GI tract, reduce gluconeogenesis and enhance insulin sensitivity by increasing peripheral glucose uptake and utilisation.

Sitagliptin(50MG)

INDICATORS

Pregnancy:B Lactation:L5 Lab:NA Food:NA

TYPICAL USAGE

Type II Diabetis Mellitus.

SIDE EFFECTS

Headache, diarrhoea, upper respiratory tract infection, nasopharyngitis.

DRUG INTERACTION

NA

MECHANISM OF ACTION

Sitagliptin inhibits dipeptidyl peptidase IV (DPP-IV), resulting in prolonged active incretin levels. Incretin hormones increases insulin synthesis and release from pancreatic ?-cells and reduces glucagon secretion from pancreatic ?-cells. Reduced glucagon secretion leads to decreased hepatic glucose production.

SUBSTITUTES

  • Zita-Met 50/500
    (10 Tablets in Tablet)
    Glenmark Pharmaceuticals Ltd
    Rs. 14.90/Tablet
    Rs.149
    save 32%
  • Janumet (50/500Mg)
    (14 Tablets in Tablet)
    Merck Sharp & Dohme (MSD)
    Rs. 22/Tablet
    Rs.308
  • Janumet (50/500Mg)
    (14 Tablets in Tablet)
    Merck Sharp & Dohme (MSD)
    Rs. 22/Tablet
    Rs.308