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There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Non-insulin dependent diabetes.
Side Effects: Nausea and stomach upset
Drug Interaction: Medicines that can increase blood sugar can reverse the action of glimepiride. These drugs include diuretics, for example, hydrochlorothiazide (Hydrodiuril, Ezide, Hydro-Par, Microzide, and many combinations with other drugs), furosemide (Lasix), corticosteroids such as prednisone and methylprednisolone (Medrol), phenytoin (Dilantin),niacin, and sympathomimetics such as pseudoephedrine (Sudafed). Beta blockers such as propranolol (Inderal) and atenolol (Tenormin) can cause low or high blood sugar.
Mechanism Of Action: This medication is an oral hypoglycemic (anti-diabetic drug), prescribed for type 2 diabetes.
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Diabetes mellitus, hyperlipoproteinaemia, insulin dependent diabetes mellitus, insulin resistance, non-insulin dependent diabetes mellitus.
Side Effects: Vasculitis, pneumonitis, malabsorption of vit B12, malabsorpton of folic acid, megaloblastic anemia, hypoglycemia, abdominal distension, flatulence, nausea, vomiting, anorexia, diarrhea, skin reactions, weight Loss, hypersensitivity.
Drug Interaction: Metformin (HCl) is known to interact with other drugs like acarbose, alcohol, amiloride (HCl), atenolol, chlorpromazine (HCl), cimetidine (HCl), digoxin, frusemide or furosemide, glibenclamide, hydrochlorothiazide, insulin aspart, ioxaglate, isoniazid. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Metformin decreases blood glucose levels by decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. These effects are mediated by the initial activation by metformin of AMP-activated protein kinase (AMPK), a liver enzyme that plays an important role in insulin signaling, whole body energy balance, and the metabolism of glucose and fats. Activation of AMPK is required for metformin's inhibitory effect on the production of glucose by liver cells. Increased peripheral utilization of glucose may be due to improved insulin binding to insulin receptors. Metformin administration also increases AMPK activity in skeletal muscle. AMPK is known to cause GLUT4 deployment to the plasma membrane, resulting in insulin-independent glucose uptake.
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Showing 5 of 93