INDICATORSPregnancy:D Lactation:L3 Lab:NA Food:NA
Angina, cardiac arrhythmia, hypertension, hyperthyroidism (adjunct), maintenance of recurrent duodenal ulcers, migraine prophylaxis, myocardial infarction, prevention of relapse in duodenal ulcer.
Agranulocytosis, hyperglycemia, severe bradycardia, bradycardia, dizziness, fatigue, nausea, vomiting, alopecia, diarrhea, dyspnea, pruritus, GI upset, elevation of liver enzymes, hyperpigmentation, sleep pattern disturbances.
Metoprolol (Tartrate) is known to interact with other drugs like alprazolam, amiodarone (HCl), aspirin, benorylate, choline magnesium trisalicylate, cimetidine (HCl), clonidine (HCl), clorazepate (K), dexamphetamine (Sulphate), diltiazem (HCl), fluoxetine (HCl), fluvoxamine (Maleate). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
INDICATORSPregnancy:D Lactation:L4 Lab:NA Food:NA
Benign gastric ulcer associated with H.pylori, Congestive heart failure (adjunct), Gastric acid reduction during anaesthesia, Heart failure, Hypertension, Iron deficiency anaemia, Mild to moderate hypertension, Prophylaxis of cardiovascular events/stroke.
Dizziness, Headache, Diarrhea, Rashes, Nausea and vomiting.
Non steroidal drugs may increase risk of deterioration of renal function.
MECHANISM OF ACTION
Ramipril is an ACE inhibitor which is metabolised into the active metabolite ramiprilat. It competitively inhibits angiotensin-converting enzyme (ACE) from converting angiotensin I to angiotensin II resulting in increased plasma renin activity and reduced aldosterone secretion. It also increases bradykinin levels. By these mechanisms, ramipril produces a hypotensive effect and a beneficial effect in CHF.