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(10 Tablets in a Strip)
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SALTS:    Finasteride (5mg) | Tamsulosin (0.4mg)

Salt Information


Pregnancy: X Lactation: L5 Lab: NA Food: NA

Typical usage: Treatment of symptomatic benign prostatic hyperplasia. Male pattern baldness.

Side Effects: Gynaecomastia, decreased libido, impotence, reduction in the volume of ejaculate, testicular pain. Hypersensitivity reactions e.g. swelling of lips and face, urticaria, rashes.

Drug Interaction: No data regarding the interactions of drug was found.

Mechanism Of Action: Finasteride is a competitive inhibitor of the enzyme 5-? reductase which converts testosterone to dihydrotestosterone (DHT), thus resulting in decreased serum levels of DHT.


Pregnancy: D Lactation: L5 Lab: NA Food: NA

Typical usage: Benign Prostatic Hyperplasia (BPH).

Side Effects: Nausea, stomach upset, skin rash, acute toxicity.

Drug Interaction: The elimination of tamsulosin from the body may be reduced by erythromycin, ketoconazole (Nizoral, Extina, Xolegel, Kuric),paroxetine (Paxil), cimetidine (Tagamet), ritonavir (Norvir), lopinavir, and other drugs that reduce the elimination of drugs by liver enzymes. Reduced elimination may lead to increased side effects of tamsulosin. PDE-5 inhibitors (for example, vardenafil [Levitra, Staxyn], Adcirca, sildenafil[Viagra, Revatio], tadalafil [Cialis]) add to the blood pressure lowering effects of tamsulosin and may result in severe blood pressure reduction.

Mechanism Of Action: Tamsulosin is an oral drug for the treatment of men who are having difficulty urinating because of benign prostatic hyperplasia (BPH). In men, the tube which carries urine from the bladder to the penis (called the urethra) travels through the prostate gland. As men get older, the prostate gland enlarges, and the muscle cells within the prostate gland and the neck of the bladder (which controls the flow of urine) tighten. The combination of enlargement and tightening of muscles compresses the urethra and obstructs the flow of urine. This results in difficulty urinating and retention of urine within the bladder. The tightening or contraction of the muscle cells is controlled by nerves. One type of nerve, the alpha adrenergic nerves, cause the muscle cells to tighten by releasing a chemical related to epinephrine (adrenalin). Tamsulosin blocks the effects of this chemical on the muscle cells and causes the muscles to relax. This results in a decrease in obstruction to the flow of urine. There are other drugs which block alpha adrenergic nerves throughout the body and which are used in treating diseases of the heart, blood vessels, and prostate for example, prazosin (Minipress), terazosin (Hytrin), doxazosin (Cardura), andalfuzosin (Uroxatral). Tamsulosin is more active against the alpha adrenergic nerves of the prostate and bladder neck than these other drugs and has a lesser effect on alpha adrenergic nerves elsewhere in the body. For this reason, tamsulosin causes fewer side effects, especially low blood pressure, than other alpha adrenergic blocking drugs. Moreover, tamsulosin therapy can be started at the optimum dose whereas other alpha adrenergic blocking drugs need to be started at low doses with the doses slowly increased over time in order to minimize the side effects. Tamsulosin was approved by the FDA in 1997.


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