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Nervup Forte

(10 Capsules in a Strip)
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Composition

SALTS:    Alpha Lipoic Acid (200 Mg) | Folic Acid (0.5 Mg) | Methylcobalamin (500 Mcg)

Salt Information

Alpha Lipoic Acid

Pregnancy: C Lactation: L3 Lab: NA Food: NA

Typical usage: Antioxitent

Side Effects: Thiamine deficiency, low blood sugar levels.

Drug Interaction: Alfa lipoic acid is known to interact with other drugs like metformin, glyburide. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Mechanism Of Action: Lipoic acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of the R-enantiomer when a racemic mixture is given. The S-enantiomer has been found to reduce the expression of GLUT-4s in cells, responsible for glucose uptake, and hence reduce insulin sensitivity.

Folic Acid

Pregnancy: A Lactation: L1 Lab: NA Food: NA

Typical usage: Folate-deficient. Megaloblastic anaemia. Prophylaxis of megaloblastic anemia in pregnancy. Prophylaxis of neural tube defect in pregnancy. Malabsorption syndromes. Antiepileptic therapy.

Side Effects: Neuropathy, bronchospasm, itchy skin eruptions, malaise.

Drug Interaction: Interacts with other drugs like deferoxamine, epoetin, fosphenytoin, methotrexate, sulphasalazine. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Mechanism Of Action: Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.

Methylcobalamin

Pregnancy: C Lactation: L3 Lab: NA Food: NA

Typical usage: peripheral neuropathy, megaloblastic anaemia

Side Effects: Anorexia, nausea, vomiting and diarrhoea.

Drug Interaction: Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives.

Mechanism Of Action: Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

No substitutes found