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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Potent mucolytic and mucokinetic agent, capable of bringing out bronchial secreation especially mucous plugs. Chronic obstructive lung disease, bronchiectesis.
Side Effects: Hypersensitivity reactions, contact allergy.
Drug Interaction: Ambroxol is known to interact with other drugs like codeine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It stimulates synthesis and release of surfactant by type IIpneumocytes. Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: Allergic rhinitis, acute coryza, allergic dermatological disorders.
Side Effects: Sinus tachycardia, hair loss, tinnitus, hypotension, insomnia, blood dyscrasias, hypotension, nausea, vomiting, tachycardia, convulsions, drowsiness, hallucinations, ataxia, hyperpyrexia, tremor, ventricular arrhythmias, dizziness, headache, fatigue, nausea, vomiting, diarrhea, constipation, dry mouth, pruritus, sedation, epigastric pain.
Drug Interaction: Loratadine is known to interact with other drugs like amprenavir, clarithromycin, erythromycin, fluconazole, fluoxetine (HCl), ketoconazole, procarbazine, quinidine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Loratadine competes with free histamine and blocks the H1 receptors. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Loratadine also suppress the release of leukotrienes from human lung fragments.