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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Adnexitis, dysmenorrhoea, inflammation, migraine, post-operative pain, post-traumatic pain, rheumatoid arthritis.
Side Effects: Dizziness, vertigo, headache, rashes, GI upset, elevation of liver enzymes, GI hemorrhage, vision disturbances, erythema multiforme.
Drug Interaction: Diclofenac is known to interact with other drugs like cholestyramine, colestipol (HCl), cyclosporin A, misoprostol, nitrendipine, sucralfate. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Diclofenac inhibits both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.
No substitutes found