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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Skeletal muscle spasticity of spinal and cerebral origin.
Side Effects: Hallucinations, Allergic reactions, Personality disturbances.
Drug Interaction: Interacts with other drugs like Alcohol, Captopril, Diazepam, Diazoxide, Lithium, Lofexidine, Loprazolam, Methyldopa, Metyrosine, Perindopril, Phenylalanine, Pioglitazone, Quinidine.
Mechanism Of Action: Baclofen is an oral and injectable medication that relaxes skeletal muscles, the muscles that move the skeleton (and also called striated muscle). Chemically, baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. GABA released by some nerves causes the activity of other nerves to decrease. It is believed that baclofen, acting like GABA, blocks the activity of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle.
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Showing 5 of 7