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Cardace H (5 Mg)

(10 Tablets in a Strip)
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Composition

SALTS:    Ramipril (5mg) | Hydrochlorothiazide (Immediate Release) (12.5mg)

Salt Information

Ramipril

Pregnancy: D Lactation: L4 Lab: NA Food: NA

Typical usage: Benign gastric ulcer associated with H.pylori, Congestive heart failure (adjunct), Gastric acid reduction during anaesthesia, Heart failure, Hypertension, Iron deficiency anaemia, Mild to moderate hypertension, Prophylaxis of cardiovascular events/stroke.

Side Effects: Dizziness, Headache, Diarrhea, Rashes, Nausea and vomiting.

Drug Interaction: Non steroidal drugs may increase risk of deterioration of renal function.

Mechanism Of Action: Ramipril is an ACE inhibitor which is metabolised into the active metabolite ramiprilat. It competitively inhibits angiotensin-converting enzyme (ACE) from converting angiotensin I to angiotensin II resulting in increased plasma renin activity and reduced aldosterone secretion. It also increases bradykinin levels. By these mechanisms, ramipril produces a hypotensive effect and a beneficial effect in CHF.

Hydrochlorothiazide (Immediate Release)

Pregnancy: B Lactation: L3 Lab: NA Food: NA

Typical usage: Disorders of calcium balance, Edema, Heart failure, Hypertension, Oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Diabetes insipidus.

Side Effects: Dizziness, Thirst, Headache, Nausea, Gout, Impotence, Polyuria, Night cramps.

Drug Interaction: None mentioned.

Mechanism Of Action: Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption.

No substitutes found