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Co Symoxyl (625 Mg)

(6 Tablets in a Strip)
Rs 78.47   per Strip Now Rs 78.47 YOU SAVE 0.0 %
6 Tablet  (1 Strip) Enter Pincode


SALTS:    Amoxicillin (500mg) | Clavulanic Acid (125mg)

Salt Information


Pregnancy: B Lactation: L1 Lab: NA Food: NA

Typical usage: Respiratory, genito-urinary, skin and soft tissue, ENT infections due to susceptible strains of Gram negative organisms like H.influenzae, E-coli, P.mirabilis and N. gonorrhoea.

Side Effects: Abscesses, acute bronchitis, bacteriuria, bronchitis, carbuncles, cellulitis, chronic bronchitis, cystitis, dental abscess, dental abscess (short-course), endocarditis, furunculosis, gonorrhoea, gynecological infections, haemophilus influenzae infections, dizziness, headache, anorexia, iarrhea, fever, abdominal pain, maculopapular rash, rashes, gastritis, indigestion, urticarial skin rash.

Drug Interaction: Amoxicillin is known to interact with other drugs like chloramphenicol, methotrexate, probenecid, rabeprazole, sodium picosulphate, tetracycline (HCl), warfarin (Na).

Mechanism Of Action: Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.

Clavulanic Acid

Pregnancy: B Lactation: L3 Lab: NA Food: NA

Typical usage: Bacterial infections, myeloablative therapy followed by bone marrow transplantation, respiratory tract infections, urinary tract infection.

Side Effects: Hypersensitivity reactions, eosinophilia, severe diarrhea, hepatic cholestasis, nausea, vomiting, diarrhea, fever, maculopapular rash, urticaria, increase in serum transaminase.

Drug Interaction: Clavulanic acid is known to interact with other drugs like demeclocycline, doxycycline, ethinyl estradiol, mestranol, methotrexate, tetracycline. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Mechanism Of Action: Clavulanic acid competitively and irreversibly inhibits a wide variety of beta-lactamases. Binding and irreversibly inhibiting the beta-lactamase results in a restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacteria. By inactivating beta-lactamase (the bacterial resistance protein), the accompanying penicillin/cephalosporin drugs may be made more potent as well.


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