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Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; And/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote.
Typical usage: 2nd generation cephalosporin for oval use, for wide variety of infections especially respiratory tract,ear and skin infections.
Side Effects: Serum sickness, pseudomembranous colitis, dizziness, headache, nausea, vomiting, diarrhea, insomnia, nervousness, abdominal pain, skin rashes, vaginitis.
Drug Interaction: Probenecid (Benemid) may increase the blood concentration of cefprozil by decreasing excretion of cefprozil by the kidney. This interaction is sometimes used to enhance the effect of cephalosporins. Combining cefprozil with aminoglycosides (for example, tobramycin) produces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney.
Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.