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Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Recurrent miscarriage, amenorrhoea, abnormal uterine bleeding, palliative treatment of advanced, inoperable endometrial carcinoma
Side Effects: GI disturbances, increased appetite, weight gain or loss, oedema, acne, allergic skin rashes, urticaria, mental depression, discomfort in breast, cough, dyspnoea.
Drug Interaction: Hydroxyprogesterone caproate is known to interact with other drugs like carbamazepine, phenytoin, ciclosporin.
Mechanism Of Action: Hydroxyprogesterone caproate stimulates luteal actions, changes in uterus and vagina as seen in early pregnancy. It also has prolonged uterotrophic effect. Contractile response of the myometrium to oxytocin is inhibited.
No substitutes found