INDICATORSPregnancy:C Lactation:L3 Lab:NA Food:NA
Acute nausea and vomiting, dyspepsia, functional dyspepsia, gastric distension pain due to pressure on the stomach, gastro-oesophageal reflux disease, nausea and vomiting, nausea and vomiting (chemotherapy induced), nausea and vomiting (L-dopa induced).
Tardive dyskinesia, parkinsonism, extrapyramidal dystonic reactions, convulsions, coma, GI disturbances, extrapyramidal effects, thirst, headache, drowsiness, diarrhea, anxiety, restlessness, insomnia, nervousness, skin rashes, dry mouth, itching, galactorrhea, breast enlargement, soreness, hyperprolactinemia.
Domperidone is known to interact with other drugs like apomorphine, bromocriptine (Mesylate), cabergoline, cinnarizine, lisuride, oxycodone, pergolide, piribedil. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting.
INDICATORSPregnancy:C Lactation:L5 Lab:NA Food:NA
Benign gastric and peptic ulcer. Erosive of ulcerative gastro-oesophageal reflux disease (GORD). Acid peptic disease.
Nausea, stomach upset, skin rash, acute toxicity.
There have been reports of an increase in the effect of the blood thinner, warfarin (Coumadin), by rabeprazole which theoretically could lead to increased bleeding. Patients taking warfarin should be monitored more frequently if they begin taking rabeprazole. Rabeprazole may reduce the elimination of cyclosporin in the liver, thereby increasing cyclosporin levels in the blood and potentially leading to cyclosporin toxicity. The absorption of certain drugs may be affected by changes in stomach acidity. Rabeprazole and other PPIs that reduce stomach acid reduce the absorption and concentration in blood ofketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, respectively. PPIs may decrease blood levels of atazanavir (Reyataz).
MECHANISM OF ACTION
Rabeprazole is an oral drug that is used for the treatment of conditions caused by acid. It is in a class of drugs called proton pump inhibitors or PPIs which block the production of acid by the stomach. Other drugs in the same class include lansoprazole (Prevacid),omeprazole (Prilosec), pantoprazole (Protonix), esomeprazole (Nexium), and dexlansoprazole (Dexilant). PPIs are used for the treatment of acid-caused conditions such as stomach and duodenal ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome. Rabeprazole, like other PPIs, blocks the pump in the wall of the stomach that secretes acid into the stomach. By blocking the pump, the secretion of acid into the stomach is decreased, and this allows ulcers in the stomach and esophagus to heal. The FDA approved rabeprazole in August 1999.
- No substitutes found