SALT INFORMATIONDomperidone(30 mg)
INDICATORSPregnancy:C Lactation:L3 Lab:NA Food:NA
Acute nausea and vomiting, dyspepsia, functional dyspepsia, gastric distension pain due to pressure on the stomach, gastro-oesophageal reflux disease, nausea and vomiting, nausea and vomiting (chemotherapy induced), nausea and vomiting (L-dopa induced).
Tardive dyskinesia, parkinsonism, extrapyramidal dystonic reactions, convulsions, coma, GI disturbances, extrapyramidal effects, thirst, headache, drowsiness, diarrhea, anxiety, restlessness, insomnia, nervousness, skin rashes, dry mouth, itching, galactorrhea, breast enlargement, soreness, hyperprolactinemia.
Domperidone is known to interact with other drugs like apomorphine, bromocriptine (Mesylate), cabergoline, cinnarizine, lisuride, oxycodone, pergolide, piribedil. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting.
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