Select to order medicines [Delhi/NCR /Bangalore /Chennai /Bhubaneswar /Hyderabad/Pune & Mumbai region.]
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; And/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote.
Typical usage: Cholangitis, Cholecystitis, Cholecytolithiasis, Cystitis, Nephrolithiasis, Papilitis, Smooth muscle spasm, Stone formation, Ureterolithiasis, Urolithiasis, Vesical tenesmus.
Side Effects: Dizziness, Headache, Nausea, Palpitation, Constipation, Insomnia, Hypotension.
Drug Interaction: Not known
Mechanism Of Action: Drotaverine inhibits phosphodiesterases hydrolysing cAMP, thereby increasing cAMP concentration, decreasing Ca uptake of the cells and changing the distribution of calcium among the cells. It may also have minor allosteric calcium channel blocking properties.
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Dysmenorrhoea, fever, inflammation, juvenile chronic arthritis, menorrhagia, migraine, musculoskeletal disorders, osteoarthritis, pain, post-operative pain, post-partum pain, rheumatoid arthritis.
Side Effects: Diarrhoea, peripheral edema, urticaria, GI bleeding, proteinuria, aplastic anemia, epidermal necrolysis, jaundice, nephrotic syndrome, interstitial nephritis, papillary necrosis, hemolysis, proctocolitis, enteritis, dizziness, headache, drowsiness, skin rashes, maculopapular rash, hematuria, elevation of liver enzymes.
Drug Interaction: Mefenamic acid is known to interact with other drugs like sulfapyridine, torasemide. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
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