Macox Zh Kid

(10 Tablets in Strip)
-10+
Tablet
(1 Strip)
Rs. 2.20 / Tablet
Rs.21.96

SALT INFORMATION

Isoniazid 1 (Captabs)(50mg)

INDICATORS

Pregnancy:C Lactation:L4 Lab:NA Food:NA

TYPICAL USAGE

Acute leukemia, Mycobacterial infection, Prophylaxis of TB, Tuberculosis, Vestibular disorders.

SIDE EFFECTS

Nausea, Vomiting, Tachycardia, Convulsions, Coma, Seizures, Urinary retention, Dizziness, Hyperreflexia, Slurred speech.

DRUG INTERACTION

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

MECHANISM OF ACTION

Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.

Rifampicin(300 mg)

INDICATORS

Pregnancy:D Lactation:L4 Lab:NA Food:NA

TYPICAL USAGE

Epilepsy (monotherapy), Iron-deficiency anaemia with chronic renal failure, Leprosy, Meningitis, Meningitis prophylaxis, Mycobacterial infection, Paget's disease of bone, Tuberculosis, Urinary tract infection

SIDE EFFECTS

Nausea, Vomiting, Anorexia, Abdominal discomfort, Orange coloration of secretions.

DRUG INTERACTION

Epilepsy (monotherapy), Iron-deficiency anaemia with chronic renal failure, Leprosy, Meningitis, Meningitis prophylaxis, Mycobacterial infection, Paget's disease of bone, Tuberculosis, Urinary tract infection

MECHANISM OF ACTION

Rifampicin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

SUBSTITUTES

    No substitutes found