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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.
Side Effects: Dry mouth, dry eyes, blurred vision, flatulence, abdominal pain, nausea, constipation, vomiting, tachycardia.
Drug Interaction: Trospium chloride is known to interact with other drugs like acetophenazine, amitriptyline, atropine, benzatropine, bromodiphenhydramine, carbinoxamine, chlorpromazine, clomipramine, cyclizine, desipramine, desloratadine, dexbrompheniramine, dimenhydrinate, donepezil, fexofenadine, flupenthixol, fluphenazine, haloperidol, hydroxyzine, imipramine, isocarboxazid, thioridazine, tranylcypromine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Trospium chloride antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder.