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Clopitorva (20 Mg)

(10 Tablets in a Strip)
Rs 188.0   per Strip Now Rs 188.0 YOU SAVE 0.0 %
10 Tablet  (1 Strip) Enter Pincode

Composition

SALTS:    Atorvastatin (10 mg) | Clopidogrel (75 mg)

Salt Information

Atorvastatin

Pregnancy: X Lactation: L5 Lab: NA Food: NA

Typical usage: Primary hypercholesterolaemia, heterozygous familial hypercholesterolaemia, homozygous familial hypercholesterolaemia or combined hyperlipidaemia.

Side Effects: Flatulence, diarrhoea, nausea, vomiting, anorexia, xerostomia, angioedema, myalgia, rash, pruritus, alopecia, allergy, infection, chest pain.

Drug Interaction: Atorvastatin is known to interact with other drugs like alvimopan, atazanavir, boceprevir, carbamazepine, clarithromycin, cyclosporine, dronedarone, erythromycin, etravirine, ketoconazole, nefazodone. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Mechanism Of Action: Atorvastatin selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway, this results in a subsequent decrease in hepatic cholesterol levels. Decreased hepatic cholesterol levels stimulates upregulation of hepatic LDL-C receptors which increases hepatic uptake of LDL-C and reduces serum LDL-C concentrations.

Clopidogrel

Pregnancy: D Lactation: L5 Lab: NA Food: NA

Typical usage: Reduction of athero-sclerotic events (MI, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent MI or established peripheral arterial disease.

Side Effects: Nausea, stomach upset, skin rash, acute toxicity.

Drug Interaction: The combination of clopidogrel with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil, Nuprin),naproxen (Naprosyn, Aleve), diclofenac (Voltaren), etodolac (Lodine),nabumetone (Relafen), fenoprofen (Nalfon), flurbiprofen (Ansaid),indomethacin (Indocin), ketoprofen (Orudis; Oruvail), oxaprozin (Daypro),piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), and mefenamic acid (Ponstel) may increase the risk of stomach and intestinal bleeding.

Mechanism Of Action: Clopidogrel bisulfate is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. Clopidogrel prevents blood clots by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors. Other drugs in this class include ticagrelor (Brilinta) and prasugrel (Effient). Clopidogrel is similar to ticlopidine (Ticlid) in chemical structure and in the way it works. Unlike ticlopidine, clopidogrel bisulfate does not cause serious reductions of white cells in the blood and, therefore, routine blood testing to determine if the white blood cell count is low is not necessary during treatment. The risk of heart attacks and strokes (which usually are caused by blood clots) is increased in patients with a recent history of strokeor heart attack, and patients with peripheral vascular disease. (Peripheral vascular disease is the same as atherosclerotic arterial disease or "hardening" of the arteries in which the arteries become narrowed. It frequently occurs in the legs and often causes claudication or pain in the legs upon walking.) Clopidogrel bisulfate is used to reduce the risk of heart attacks and strokes in these patients.

Substitutes

Storclop 10
(10 Tablets in a Strip)
Ranbaxy Laboratories Ltd
MRP Rs. 109.0
Rs. 10.9/Tablet
42.0%