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Atorfit Cv (10 Mg)

(10 Tablets in a Strip)
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Composition

SALTS:    Atorvastatin (10 mg) | Fenofibrate (75 mg)

Salt Information

Atorvastatin

Pregnancy: X Lactation: L5 Lab: NA Food: NA

Typical usage: Primary hypercholesterolaemia, heterozygous familial hypercholesterolaemia, homozygous familial hypercholesterolaemia or combined hyperlipidaemia.

Side Effects: Flatulence, diarrhoea, nausea, vomiting, anorexia, xerostomia, angioedema, myalgia, rash, pruritus, alopecia, allergy, infection, chest pain.

Drug Interaction: Atorvastatin is known to interact with other drugs like alvimopan, atazanavir, boceprevir, carbamazepine, clarithromycin, cyclosporine, dronedarone, erythromycin, etravirine, ketoconazole, nefazodone. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Mechanism Of Action: Atorvastatin selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway, this results in a subsequent decrease in hepatic cholesterol levels. Decreased hepatic cholesterol levels stimulates upregulation of hepatic LDL-C receptors which increases hepatic uptake of LDL-C and reduces serum LDL-C concentrations.

Fenofibrate

Pregnancy: C Lactation: L3 Lab: NA Food: NA

Typical usage: Hypercholesterolaemia, hyperlipoproteinaemia, prophylaxis of NSAID-associated gastric or duodenal ulcer.

Side Effects: Hepatitis, rhabdomyolysis, headache, diarrhea, myalgia, constipation, skin rashes, impotence, decrease in libido.

Drug Interaction: Fenofibrate is known to interact with other drugs like Acenocoumarol, Anisindione, Cerivastatin, Dicumarol, Lovastatin, Pravastatin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Mechanism Of Action: Fenofibrate exerts its therapeutic effects through activation of peroxisome proliferator activated receptor a (PPARa). This increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III.

No substitutes found