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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: Gout, hyperuricemia.
Side Effects: Fever, neutropenia, thrombocytopenic purpura, angina, slurred speech, blurred vision, irregular heart beat, leukopenia, flatulence, dizziness, headache, nausea, vomiting, diarrhea, constipation, abdominal pain, dry mouth, rashes, gastritis, mouth ulcers, dyspepsia, asthenia, arthralgia, muscle cramps.
Drug Interaction: Febuxostat is known to interact with other drugs like mercaptopurine (Monohydrate). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Febuxostat non-competitively block the molybdenum pterin center which is the active site on xanthine oxidase. Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid.
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Showing 5 of 30