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There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Superficial mucosal candidiasis. Candidal balanitis, vaginal candidiasis. Dermatophytosis, pityriasis, versicolor and candida infections. Cryptococcal infections including meningitis, systemic candidasis. Prevention of relapse following a primary course of antifungal treatment for acute cryptococcal infections in patients with aids. Prophylaxis of fungal infections in immunocompromised patients.
Side Effects: Elevated alkaline phosphatase concentration, elevated hepatic enzymes, dizziness, headache, nausea, vomiting, diarrhea, abdominal pain, rashes, hypokalemia, pallor, anaphylaxis, leucopenia.
Drug Interaction: Fluconazole is known to interact with other drugs like alfentanil (HCl), aliskiren, alprazolam, amitriptyline (HCl), artesunate, astemizole, bosentan, celecoxib, chlorpropamide, cisapride, cyclosporin A, fosphenytoin, hydrochlorothiazide, loratadine, losartan (K), nortriptyline (HCl), phenytoin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Fluconazole interacts with 14-? demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents.
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