Select to order medicines [Delhi/NCR /Bangalore /Chennai /Bhubaneswar /Hyderabad/Pune & Mumbai region.]
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Typical usage: Adjunct in heart failure, adjunct in stable moderate to severe heart failure, adjunctive therapy without valproate, all forms of epilepsy, candidiasis, fungal infection, hormone-mediated secretory diarrhea, hormone-mediated secretory diarrhea (but can be of benefit in refactory cases), hormone-mediated secretory diarrhea (can be benefit in refactory cases), nausea and vomiting.
Side Effects: Elevated alkaline phosphatase concentration, elevated hepatic enzymes, dizziness, headache, nausea, vomiting, diarrhea, abdominal pain, rashes, hypokalemia, pallor, anaphylaxis, leucopenia.
Drug Interaction: Fluconazole is known to interact with other drugs like alfentanil (HCl), aliskiren, alprazolam, amitriptyline (HCl), artesunate, astemizole, bosentan, celecoxib, chlorpropamide, cisapride, cyclosporin A, fosphenytoin, hydrochlorothiazide, loratadine, losartan (K), nortriptyline (HCl), phenytoin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action: Fluconazole interacts with 14-? demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents.
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