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1

SALT INFORMATION

Coenzyme Q10(100 mg)

TYPICAL USAGE

Coenzyme Q10 (CoQ10), also known as ubiquinone is a naturally occuring vitamin like substance found in the body.. It is used as a preventive therapy for aging heart problems, and in treating heart failure, gum diseases, type 2 diabetes and high blood pressure. CoQ10 is also being used as supportive therapy for various nerve and muscle-related disorders, as well as few rare inherited disorders. CoQ10 should never be used in place of prescribed medcations for any of the above diseases, as it cannot cure these diseases when taken alone

SIDE EFFECTS

Most people tolerate CoQ10 well. Following side-effects may be seen:Skin itching and rashes, fungal infections of skin, nausea, upset stomach, vomiting, constipation, diarrhea, gas, heartburn, stomach pain, loss of appetite, indigestion, low energy, fainting, falling, fatigue, insomnia, trembling, changes in attention, headaches, abnormal breathing, bronchitis, coughing, flu-like symptoms, lung inflammation, respiratory tract infection, runny nose, infection/inflammation of air-cavities (sinuses) around the nose, sore throat, changes in sperm motility, muscle pain, night sweats, hearing loss, heart attack, and chest pain have been reported. Most of these side-effects are mild in nature, although some may be serious. Inform your doctor if you experience any of these side-effects.

DRUG INTERACTION

* CoQ10 may reduce the effectiveness of warfarin, or it may increase the risk of bleeding when taken with blood thinners such as aspirin, clopidogrel, or heparin. * CoQ10 may further decrease blood pressure if taken concomitantly with other blood pressure lowering medicine such as captopril, enalapril, losartan, valsartan, diltiazem, amlodipine, hydrochlorothiazide, furosemide, hydralazine  * CoQ10 may affect thyroid hormone levels and interact with synthetic thyroid agents. * CoQ10 may interact with                        -acetylsalicylic acid and other anti-inflammatory agents                       -medicines that may affect the immune system such as immunoglobulins                       -medicines that may affect the nervous system such as Alzheimer's agents,                                 amitriptyline, dopamine agonists/antagonists, antidepressants. ,                       -medicines used to treat diseases of the heart like amiodarone, methyldopa etc.                       -medicines that enhance exercise performance such as anabolic androgenic                                steroids                       -medicines that promote urination                        -medicines that treat asthma * CoQ10 may also interact with alpha-lipoic acid * CoQ10 may also interact with doxorubicin, drugs used to treat diseases of the eye, cholesterol lowering agents like statins, ezetimibe, fenofibrate, drugs used to improve fertility, hormonal agents, iridium, mercury, nicotine, nitroglycerin, orlistat and weight loss mediciens, skin medicines, steroids etc. 

MECHANISM OF ACTION

CoQ10 is a fat-soluble compound (chemical) synthesized by the body, required for the proper function of many organs and chemical reactions in the body. It also acts as an antioxidant (substance that protects against cell damage) by neutralizing the free radicals (waste products formed in the body during energy production) 

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration.There are no established doses for CoQ10.  * Adult: dose may range from 100 mg to 2400 mg daily in divided doses depending upon the intended use. * Children (under 18 years): dose may range from 20 mg to 1000 mg daily in divided doses depending upon the intended use.

DOs and DON'Ts

* Always consult your doctor before taking CoQ10 as a supplementary therapy. * Precautions must be taken if you are suffering for liver problems. * Diabetic patients on CoQ10 supplementation must closely monitor their blood sugar levels for sudden drop is sugar levels. * Patients suffering from high blood pressure must also use CoQ10 with caution and monitor their blood pressure regularly.

CONTRA INDICATIONS

Patients with severe liver condition should consult the doctor before using CoQ10.

FAQ

Q.Is Coenzyme Q10 a vitamin?No, Coenzyme Q10 is not a vitamin. It is a vitamin-like substance found throughout the bodyQ.Is Coenzyme Q10 FDA approved?Yes, At least one formulation of CoQ10 has been FDA-approved as an orphan drug for rare genetic disorders such as mitochondrial deficiencies.Q.Is Coenzyme Q10 natural?Yes, Coenzyme Q10 is natural as it is synthesized in the human body. CoQ10 is found in most cells of the body, with high concentrations in the heart, liver, kidney, and pancreas. Q.Is Coenzyme Q10 safe during pregnancy?Safety of Coenzyme Q10 has not been established in pregnant women. Consult your doctor before using CoQ10 during pregnancy.Q.Is Coenzyme Q10 good for weight loss?It is not yet studied or established in humans whether Coenzyme Q10 supplementation is beneficial for weight loss.Q.Is Coenzyme Q10 safe/ bad for you?If taken as a supplement at the prescribed doses Coenzyme Q10 is safe, and not bad for you. Although, it may cause some side effects.Q.Is Coenzyme Q10 a blood thinner/ blood thinning agent/ Plavix (clopidogrel)?No, Coenzyme Q10 does not have any known effects on blood thinning. However, if given with a blood thinning agent, it may increase the risk of bleeding.Q.Is Coenzyme Q10 effective in statin myopathy?There is some evidence that coenzyme Q10 might reduce muscle pain caused due to statin therapy which are used to lower the cholesterol. However, more research is needed to determine whether coenzyme Q10 supplementation might be beneficial.Q.Can I take Coenzyme Q10 with lisinopril?Lisinopril is prescribed for high blood pressure. CoQ10 may be prescribed along with the blood pressure lowering medications to aid their effect. However, combined use might cause your blood pressure to go too low.Q.Can I take Coenzyme Q10 with Lipitor/Crestor?Statins are cholesterol lowering drugs. Coenzyme Q10 has been found to be beneficial in statin induced muscle pain (myopathy) and may be prescribed together if you experience this side-effect. However, coenzyme Q10 is known to interact adversely with statins. Consult your physician before taking statins and CoQ10 together.Q.Can I take Coenzyme Q10 with citalopram?There is some evidence that coenzyme Q10 might interact with antidepressants such as citalopram. Please consult your doctor before using coenzyme Q10 while on citalopram therapy.Q.Can I take Coenzyme Q10 with fish oil?There are no known serious interactions between coenzyme Q10 and fish oil.Q.Can I take Coenzyme Q10 with warfarin?Taking coenzyme Q10 with warfarin must be avoided, as it may increase the risk of bleeding.Q.Can I take Coenzyme Q10 with other vitamins/multivitamins?There are no known serious interactions between coenzyme Q10 other vitamins; However, please consult your doctor before using coenzyme Q10 with other vitamins or multivitamin supplementation.Q.Can I take Coenzyme Q10 with Synthroid?Coenzyme Q10 may affect thyroid hormone levels and interact with synthetic thyroid agents such as Synthroid. Consult your doctor before taking Synthyroid and CoQ10 together.Q.Can I take Coenzyme Q10 with atenolol?There is some evidence that coenzyme Q10 might interact with betablockers such as atenolol and cause excessive lowering of blood pressure. Please consult your doctor before using coenzyme Q10 while on atenolol therapy.Q.Does coenzyme Q10 reduce/lower blood pressure?Few clinical studies have shown that coenzyme Q10 can slightly reduce blood pressure. If given with a blood pressure lowering medicine, it may excessively reduce blood pressure.Q.Does coenzyme Q10 cause weight gain?No, Coenzyme Q10 does not have any known effects on body weight.Q.Does coenzyme Q10 reduce Cholesterol/triglycerides?No, Coenzyme Q10 does not have any known cholesterol / triglyceride lowering effects.Q.Does coenzyme Q10 gives you energy?Coenzyme Q-10 does participate in the energy production.Q.Does coenzyme Q10 cause insomnia/ gas?Yes, Coenzyme Q10 can rarely cause insomnia, and may even cause gas.Q.Does coenzyme Q10 cause hair loss?No, Coenzyme Q10 does not have any known effects on hair loss.Q.Does coenzyme Q10 cause improve egg quality?No, Coenzyme Q10 does not have any known effects on egg quality.Q.Is Coenzyme Q10 good for your skin and heart?Yes, Coenzyme Q10 supplementation is known to have protective effects on the heart. Due to its antioxidant effects, it may be good for your skin.

FURTHER INFORMATION

1.http://www.nlm.nih.gov/medlineplus/druginfo/natural/938.html2.http://lpi.oregonstate.edu/infocenter/othernuts/CoQ10/3.http://www.mayoclinic.org/drugs-supplements/coenzyme-q10/interactions/hrb-20059019

Omega-3 Fatty Acids(150 mg)

TYPICAL USAGE

* Omega-3-fatty acids are used together with other medicines for treatment after a heart attack (myocardial infarction) to reduce the increased levels of triglycerides (fats). It is also used for lowering cholesterol and lipid levels.They may also play protective roles in cancer, stroke (blood supply to a part of the brain is suddenly cut off, also called brain attack), heart disease, systemic lupus erythematosus (SLE; a type of chronic autoimmune [body's immune system attacks and destroys healthy body tissue by mistake] disease that can affect almost any organ system), eczema (a type of itchy skin rash), and rheumatoid arthritis (inflammatory disorder that typically affects the small joints in hand and feet).

SIDE EFFECTS

* Common; abdominal pain, distention, constipation, diarrhea, indigestion (dyspepsia), gas, belching, acid reflux, nausea (urge to vomit), vomiting * Uncommon: high blood sugar, gout, dizziness, poor taste, headache, low blood pressure (hypotension), nose bleed, blood in stool (melena), rash * Rare: allergic reactions, hives, urticaria (itching of skin), liver problems.

DRUG INTERACTION

* Omega-3-fatty acid may interact with anticoagulants (medicines used as blood thinners) such as warfarin and increase the bleeding tendency.

MECHANISM OF ACTION

* Omega-3-fatty acids are an essential part of cell membranes throughout the body and affect the function of the cell membranes (receptors). They provide the starting point for making hormones that regulate blood clotting, contraction and relaxation of artery walls, and inflammation. They also bind to receptors in cells that regulate some genetic function.

DOSAGE

* Always follow the instructions of doctor regarding dosage, duration and frequency of use. * Adult 1000 mg (1 gram) omega-3-fatty acid once a day. Do not take more than 3 grams daily. * After heart attack: 1000 mg omega-3-fatty acid once a day. * In hypertriglyceridemia (increased levels of triglycerides): 2000-4000 mg daily in divided doses.

DOs and DON'Ts

*     Do not use this drug if you are allergic to fish or shellfish * Omega-3-fatty acid should be taken with caution * if you had a recent surgery or trauma * If have kidney or liver problems * If you are suffering from uncontrolled diabetes. * Omega-3-fatty acid should be taken with meals to minimize the side effects particularly related to stomach and intestine (gastrointestinal) disturbances.

CONTRA INDICATIONS

* Patients with known hypersensitivity to omega-3-fatty acid or fish liver oils. * Children under 18 years of age. * Pregnant or breast feeding women

FAQ

Q. Do omega-3-fatty acids work/ good for you?Yes, omega-3-fatty acids are essential components of your body and supplementation works in preventing major diseases such as cancers, stroke (blood supply to a part of the brain is suddenly cut off, also called brain attack), heart disease, systemic lupus erythematosus (SLE; a type of chronic autoimmune disease where body's immune system attacks and destroys one’s own healthy body tissue by mistake ), eczema (a type of itchy skin rash), and rheumatoid arthritis (inflammatory disorder that typically affects the small joints in hand and feet).Q. Are omega-3-fatty acids good for skin? No known effects of omega-3-fatty acids on skin are known yet.Where are omega 3 fatty acids found/ available in which foods?Omega-3-fatty acids are mainly found in various types of fishes (anchovies, bluefish, herring, mackerel, salmon, sardines, lake trout, and tunas); some vegetable oils such as rapeseed (canola), and flaxseed, and in walnuts; some green vegetables, such as Brussels sprouts, kale, spinach, and salad greens; eggs and dairy products.Q. Does olive oil contain omega-3-fatty acids?Yes, olive oil contains omega-3-fatty acids but in small amounts.Q. Do omega-3-fatty acids cause weight gain/ loss?No, omega-3-fatty acids do not have any known effects on weight gain/ loss.Q. Do omega-3-fatty acids help lower cholesterol and triglycerides?Yes, omega-3-fatty acids help to reduce increased levels of triglycerides as an additive therapy along with other cholesterol lowering drugs. However, its effect in reducing high levels of bad cholesterol or increasing the level of good cholesterol is neither significant nor consistent.Q. How do omega-3-fatty acids reduce inflammation?When omega-3-fatty acids are consumed, they decrease the formation of various chemicals in the body (prostaglandin, thromboxane A2, leukotrienes) which are pro-inflammatory in nature and induce systemic inflammation. By inhibiting these chemicals omega-3-fatty acids reduce inflammation in the body.Q. How do omega 3 fatty acids help the brain?Omega-3 fatty acids are important for brain cells because omega-3s provide energy and are a part of the cell membranes of the brain cells.Q. Do omega-3-fatty acids help hair growth?No, omega-3-fatty acids do not have any known effects on hair growth.Q .Are omega-3-fatty acids the same as fish oil?Omega-3-fatty acids are present in fish oils. Are omega-3-fatty acids a vitamin?No, omega-3-fatty acids are fatty acids that are building blocks of fats and are vital nutrients essential for various processes of the body.

FURTHER INFORMATION

* Product Information leaflet: http://www.medicines.org.uk/emc/medicine/29753 * Summary of Product characteristics: http://www.medicines.org.uk/emc/medicine/29767%20-%20PHARMACODYNAMIC_PROPS * Wardhana, Surachmanto ES, Datau EA. The role of omega-3 fatty acids contained in olive oil on chronic inflammation. Acta Med Indones. 2011 Apr;43(2):138-43. ( http://www.ncbi.nlm.nih.gov/pubmed/21785178 ) * Other sources: http://www.webmd.com/healthy-aging/omega-3-fatty-acids-fact-sheet * http://www.hsph.harvard.edu/nutritionsource/omega-3-fats/

L-Arginine(100 mg)

TYPICAL USAGE

L-Arginine is used for congestive heart failure, chest pain, high blood pressure, and coronary artery disease. L-arginine is also used for recurrent pain in the legs due to blocked arteries, decreased mental capacity in the elderly, erectile dysfunction, male infertility. L-arginine for preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation of the digestive tract in premature infants.

SIDE EFFECTS

Abdominal pain, bloating, diarrhea, gout, blood abnormalities, allergies, airway inflammation, worsening of asthma, and low blood pressure.

DRUG INTERACTION

L-Arginine is known to interact with other drugs like captopril, enalapril, losartan, valsartan, diltiazem, amlodipine, hydrochlorothiazide, furosemide, sildenafil, nitroglycerin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

L-arginine's activities, including its possible anti-atherogenic actions, may be accounted for by its role as the precursor to nitric oxide or NO. NO is produced by all tissues of the body and plays very important roles in the cardiovascular system, immune system and nervous system. NO is formed from L-arginine via the enzyme nitric oxide synthase or synthetase (NOS), and the effects of NO are mainly mediated by 3,'5' -cyclic guanylate or cyclic GMP. NO activates the enzyme guanylate cyclase, which catalyzes the synthesis of cyclic GMP from guanosine triphosphate or GTP. Cyclic GMP is converted to guanylic acid via the enzyme cyclic GMP phosphodiesterase. NOS is a heme-containing enzyme with some sequences similar to cytochrome P-450 reductase. Several isoforms of NOS exist, two of which are constitutive and one of which is inducible by immunological stimuli. The constitutive NOS found in the vascular endothelium is designated eNOS and that present in the brain, spinal cord and peripheral nervous system is designated nNOS.

CONTRA INDICATIONS

Hypersensitivity

Cyanocobalamin(750 mcg)

TYPICAL USAGE

Addisonian pernicious anaemia, Congenital cobalamine malabsorption, Congenital intrinsic factor deficiency, Homocystenemia, Ileal resection, Methylmalonylacidurias, Nutrition deficiency, Post gastrectomy vit B-12 deficiency, Transcobalamin II deficiency, and can also be given in adjunctive therapy as an alternative drug of choice in Vitamin-B12 defeciency of dietary origin.

SIDE EFFECTS

Hypersensitivity reactions, Shivering, Dyspnea, Persistant urticaria, Bronchospasm.

DRUG INTERACTION

Cyanocobalamin is known to interact with other drugs like Alcohol, Chloramphenicol, Cholestyramine, Colchicine, Colchicine, Epoetin, Glucose, Neomycin, Neomycin, Omeprazole.

MECHANISM OF ACTION

Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.

CONTRA INDICATIONS

Anaphylactic reactions,Tobacco amblyopia.

Elemental Zinc(15 mg)

TYPICAL USAGE

Zinc is used for treatment and prevention of zinc deficiency and its consequences, including stunted growth and acute diarrhea in children, and slow wound healing. It is also used for boosting the immune system, treating the common cold and recurrent ear infections, and preventing lower respiratory infections. It is also used for malaria and other diseases caused by parasites. Zinc is also used for an eye disease called macular degeneration, for night blindness, and for cataracts. It is also used for asthma; diabetes; high blood pressure; acquired immunodeficiency syndrome (AIDS); and skin conditions such as psoriasis, eczema, and acne.

SIDE EFFECTS

Taking high amounts of zinc is likely unsafe. High doses above the recommended amounts might cause fever, coughing, stomach pain, fatigue, and many other problems.

DRUG INTERACTION

Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval.

MECHANISM OF ACTION

Zinc is needed for the proper growth and maintenance of the human body. It is found in several systems and biological reactions, and it is needed for immune function, wound healing, blood clotting, thyroid function. Zinc plays a key role in maintaining vision, and it is present in high concentrations in the eye. Zinc deficiency can alter vision, and severe deficiency can cause changes in the retina (the back of the eye where an image is focused).

CONTRA INDICATIONS

NA

SUBSTITUTES

No substitutes found

INTERACTIONS

Can I take 4uq10 during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take 4uq10 while breastfeeding/lactation?

Moderately safe: No studies have been conducted in breastfeeding women, however there is possibility of ill effect to the breastfed infants; or studies conducted in breastfeeding women show minimal non-threatening side effects to the infants. Drugs should be given only if the potential benefit justifies the potential risk to the infant. Patients should follow the advice of the doctor regarding its use.

Can I take 4uq10 with alcohol?

No studies found