Domperidone is used to treat vomiting and urge for vomiting induced by drugs and diseases, post-meal stomach discomfort, regurgitation of stomach contents into the food-pipe, and indigestion.
Dry mouth, anxiety, headache, sleepiness, loose stool, rash, itching, increase in level of hormone prolactin in blood, painful or tender breasts, discharge from breasts, weakness, involuntary movements of lips, face, trunk, tongue,, and other parts of the body, Parkinson’s disease-like symptoms, abnormal posture such as a twisted neck, severe allergic reactions leading to swelling of hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing, skin rash, fast heartbeat etc.
Ketoconazole or erythromycin can hinder domperidone's CYP3A4 mediated first pass metabolism. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Domperidone works by helping to move food faster through your food pipe, stomach and gut. This prevents food from staying in the same place for too long. It also helps stop food flowing the wrong way back up your food pipe. It also regulates vomiting and sickness.
Omeprazole is used to treat regurgitation of acid and stomach contents into the food pipe (gastro-oesophageal reflux disease) causing pain, inflammation and heartburn, ulcers in the upper part of the intestine (duodenal ulcer) or stomach (gastric ulcer),ulcers which are infected with bacteria called ‘Helicobacter pylori’, ulcers caused by pain-killers (Non-Steroidal Anti-Inflammatory Drugs), and too much acid in the stomach caused by a growth in the pancreas (Zollinger-Ellison syndrome).
Diarrhea, stomach pain, constipation, excessive passage of wind, urge to vomit, and vomiting.
Omeprazole interacts with nelfinavir, atazanavir, saquinavir, anti-fungal drugs (ketoconazole, itraconazole, posaconazole or voriconazole), digoxin, diazepam, phenytoin, blood-thinners (warfarin or other vitamin K blockers), rifampicin, tacrolimus, cilostazol, clopidogrel, erlotinib, methotrexate, amoxicillin and clarithromycin . Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Omeprazole, a proton pump inhibitor, blocks the enzyme in the stomach wall that produces acid. This reduces the acid production in the stomach and reduces gastric acidity.
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Can I take Aciloc Rd(20mg) during pregnancy?
Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.