Aciloc Rd(20mg)

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Composition

Domperidone(10mg),Omeprazole(20mg)

SALT INFORMATION

Domperidone(10mg)

TYPICAL USAGE

Domperidone is used to treat vomiting or nausea caused due to indigestion, diseases or drugs. It is also used to relieve fullness of stomach, belching and heavy bloating, gas and heartburn for a longer period up to 2 weeks.

SIDE EFFECTS

* Common: Dry mouth. * Uncommon: Headache, anxiety, sleeplessness, diarrhea, pain or tenderness in the breasts or discharge from breasts, rashes, itching, loss of interest in sex, and weakness. * Rare: Increased prolactin levels in the blood. * Side effects likely to happen in children are agitation, nervousness, fits, irritability and drowsiness. * Possible side effects due to high dosage (above 30 mg per day) and in elderly (> 60 years of age) are, heart rhythm disorder and cardiac arrest.

DRUG INTERACTION

* Domperidone may interact with and should not be taken with drugs used to treat problems of the heart-beat (qunidine, amiodarone), bacterial or fungal infections (pentamidine,erythromycin), allergies (mizolastine), malaria (chloroquine), cancer (vincamine), psychosis (haloperidol), depression (sitalopram) and problems of gastro-intestinal tract (cisapride) due to increased risk of cardiac problems.  * Drugs that inhibit the liver enzyme CYP3A4 (ketoconazole, fluconazole, clarithromycin, diltiazem and verapamil) may result in increased blood levels of domperidone. Domperidone may impact the effects of drugs such as bromocriptine.  * Drugs like anti-muscarinics (atropine) and opoid analgesics/ pain killers (codeine) may affect the action of domperidone.  * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Domperidone belongs to a class of medicines known as anti-emetics. Domperidone acts by helping food move faster through the food pipe, stomach and gut; thus normalising the digestion process.

DOSAGE

* Always follow the instructions of doctor regarding the dosage and duration  * Short-term treatment of nausea and vomiting (up to 48 hours) in adults and children above 16 years of age: 10 mg tablets thrice a day and one tablet at night or as syrup (1mg/ml) two or three times a day. * Treatment of discomfort and nausea experienced after food and drink for up to 2 weeks in adults and children above 16 years of age: 10 mg tablets thrice a day and one tablet at night or syrup taken two to three times a day. * Not more than 4 tablets should be taken in a 24-hour period

DOs and DON'Ts

* Do not take Domperidone if you are allergic to it or to any other content in the tablets. * Do not take the medicine if you notice black, tarry stools (bowel motions) or blood in your stools, blockage or tear in the intestines or if you have a tumor of the pituitary gland (prolactinoma). * Do not take the drug if you have moderate to severe liver disease, heart problems (irregular heart rate or heart failure) or abnormal salt levels in the blood. * Do not crush or chew the tablets, swallow them whole with a glass of water. * Do not take the drug if you intend to drive or operate heavy machinery as it may cause drowsiness. * Always take the tablets 15 to 30 minutes before meals and, if needed, before going to bed at night.  * Consult your doctor if you are above 60 years of age and taking domperidone for a long period of time. * Inform your doctor if you are already taking medicines for fungal infections (ketoconazole) or antibiotics (e.g. gentamycin, erythromycin).

CONTRA INDICATIONS

* Domperidone should not be given to children below 16 years of age. * The medicine should not be given to patients who are taking drugs used for heart-beat problems (cardiac arrhythmia) such as quinidine or antibiotics, antifungals, drugs used for treatment of cancer, allergies, malaria, and gastro-intestinal problems.  * Domperidone should not be used when stimulation of the gastric motility could be harmful: gastro-intestinal haemorrhage, mechanical obstruction or perforation.

FAQ

Q. What is Domperidone/ domstal used for and how long can I take it?Domperidone (also known as domstal) is used for the treatment of short-term (upto 48 hours) and long-term (upto 2 weeks) problems of nausea, vomiting, belching, gas, heartburn and bloating (not to be confused as laxative, steroid or antacid). Always take the drug exactly as your doctor has told you to.Q. Can I take domperidone for morning sickness?It is advisable to consult your doctor before taking the medicine if you are pregnant.Q. Is domperidone an over the counter drug?No, domperidone is not an OTC drug and it is not advisable to take it without a prescription.Q. Can I take domperidone with citalopram?Domperidone may increase the sedative effect of citalopram and may interact with other drugs like antibiotics, pain-killers or anti-fungals. Consult your doctor if you are taking any of these medicines.Q. Does domperidone cause weight-gain?No. Domperidone does not cause weight-gain. If you notice an abnormal weight-gain, visit your doctor.Q. Is domperidone safe?Domperidone is relatively safe drug if used in prescribed dose for prescribed duration as advised by your doctor. If you are a pregnant or lactating female, please consult your doctor before taking the drug.Q. Does domperidone raise the blood pressure or cause depression?These effects are generally not seen with use of domperidone. But if you are experiencing these side effects, please consult your doctor.

FURTHER INFORMATION

* Patient information leaflet. https://www.medicines.org.uk/emc/PIL.23070.latest.pdf * Summary of product characteristics. https://www.medicines.org.uk/emc/medicine/23070 * Summary of product characteristics. https://www.medicines.org.uk/emc/medicine/29304

Omeprazole(20mg)

TYPICAL USAGE

Omeprazole is used to treat frequent persistent heartburn, gastro-esophageal reflux disease (GERD; flow of bitter fluid into mouth, and upper abdominal/ epigastric pain); and other diseases caused by excessive stomach acid. It is also used to help in the healing of the food pipe (esophagus) when it gets damaged by excessive stomach acid ( erosive esophagitis). 

SIDE EFFECTS

* Common: Urge to vomit, vomiting, abdominal pain, constipation, diarrhea, gas (flatulence), and headache. * Uncommon: Inability to sleep (insomnia), dizziness, sleepiness (somnolence), sensation of spinning or rotation (vertigo), feeling of discomfort (malaise), itching of skin (pruritus), rash, rashes due to allergy (urticaria); redness, warmth, pain and swelling of skin (dermatitis); tingling of the skin (paresthesia), swelling in the hands or legs (peripheral edema), fracture of the hip, wrist or spine; increased liver enzymes, and deficiency of vitamin B12 can occur. * Rare: Hypersensitivity or serious allergic reaction (anaphylactic reaction) or shock; confusion, depression, agitation, hair loss (alopecia), blurred vision, swelling of the tissues in kidney (interstitial nephritis), dry mouth, taste disturbance, fungal infection in digestive system (gastrointestinal candidiasis) or sores or ulcers in mouth and lips (stomatitis); muscle, joint, or bone pain or stiffness (arthralgia); low blood sodium level (hyponatremia), low white blood cell and platelet.

DRUG INTERACTION

* Omeprazole decrease the effect of atazanavir and nelfinavir (used to treat HIV infection). * Rifampicin (used for treatment of tuberculosis) and St John's wort (used to treat depression) decrease the omeprazole levels in blood. * Omeprazole along with digoxin (used for heart problems) or water tablets may increase the risk of low magnesium level in blood. * Omeprazole may interact with other drugs including tacrolimus, methotrexate, erlotinib; clopidogrel (used to prevent blood clots), posaconazole, ketoconazole, itraconazole, or voriconazole (used to treat infections caused by a fungus); citalopram, imipramine, or clomipramine (used to treat depression); diazepam (used to treat anxiety, relax muscles or in epilepsy), phenytoin (used in epilepsy), cisapride (used for indigestion and heartburn), warfarin or other vitamin K blockers (used to thin your blood), and cilostazol (used to treat intermittent claudication).  * Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Omeprazole belongs to class of medications called proton pump inhibitors. It blocks the activity of the proton pumps in the stomach wall that produce acid, thereby reducing the amount of acid produced in the stomach.

DOSAGE

Always follow the instructions of doctor regarding the dosage and duration  * Treatment of indigestion/acidity: 10 mg -80mg or up to 20 mg once daily for 2-8 weeks.                            -Children (1 year of age; 10-20 kg): 10 mg or up to 20 mg once daily;                             -Children (≥ 2 years of age; > 20 kg): 20 mg or up to 40 mg once daily.

DOs and DON'Ts

* Take omeprazole tablets one hour before a meal * Do not chew or crush the tablets because the tablets are coated with enteric coating which stops the medicine from being broken down by the acid in your stomach. It is important not to damage the tablets. * When using Omeprazole long-term, take a calcium  with vitamin D supplement daily to prevent bone loss * Do not take a double dose (two doses at the same time) to make up for a forgotten dose. * Do not start or continue the omeprazole tablets and consult your doctor If  you are allergic to omeprazole or any of the other ingredients of this medicine and other proton pump inhibitor medicines (e.g, pantoprazole, lanzoprazole, rabeprazole, esomeprazole)

CONTRA INDICATIONS

* Do not take omeprazole if you are allergic to it, to substituted benzimidazoles or to any other ingredients of the drug. * It should not be given along with an HIV drug called nelfinavir and drug used for prevention of heart attack and stroke (hemiplegia) e.g., clopidogrel.

FAQ

Q.Is omeprazole the same as Prilosec/Omez/Omezol or Ocid? Yes. These are the brand names for omeprazoleQ.What is omez?Omez contains omeprazole. It is a proton pump inhibitor which suppresses acid production in stomach. It is not antacid which reacts and neutralizes acid. It is not an antibiotic as it does not kill bacteria.Q.Is omeprazole gluten free?Yes. Omeprazole is gluten free. Please refer to package insert of the prescribed brand before use.Q.Is omeprazole available over the counter?Omeprazole although available over the counter, it should be taken only on doctor’s advice. Q.Can I take omeprazole for irritable bowel syndrome (IBS), or nausea?Omeprazole can be used for nausea or other gastric acidity related problems. Please consult your doctor for your medical condition and before taking the drug.Q.Can I take omeprazole forever?No. Long term use of omeprazole increases the risk of wrists, hips, or spine fracture.Q.Can I take omeprazole with ranitidine, paracetamol, doxycycline, or metronidazole?Yes. You can take omeprazole with ranitidine, paracetamol, doxycycline, or metronidazole.Q.Can I take omeprazole with Synthroid (levothyroxine sodium), or Tums (calcium supplements)?Yes. You can take omeprazole with Synthroid (levothyroxine sodium), or Tums (calcium supplements).Q.Does omeprazole cause weight gain?Omeprazole may cause weight gain. Please consult your doctor if you are experiencing the same.

FURTHER INFORMATION

1.Summary of product characteristics. https://www.medicines.org.uk/emc/medicine/72492.Patient information leaflet. https://www.medicines.org.uk/emc/PIL.26923.latest.pdf

SUBSTITUTES

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INTERACTIONS

Can I take Aciloc Rd(20mg) during pregnancy?

Studies in animals have shown risk to fetus, however there are no sufficient studies in humans. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.

Can I take Aciloc Rd(20mg) while breastfeeding/lactation?

Contraindicated: The drug should not be used by breastfeeding women, as evidences from studies have shown that there is a high risk of causing significant damage to infants.

Can I take Aciloc Rd(20mg) with alcohol?

No studies found