SALT INFORMATIONSpironolactone(50 mg)
Spironolactone is used for treatment of edema (water retention) due to disease of heart , liver or kidney. It is a pottasium sparing diuretic (prevents loss of pottasium) and so used with other diuretics.
Diarrhea, Drowsiness, Dizziness, Mental confusion.
Sodium excretion effect may be inhibited by aspirin. May reduce ulcer-healing properties of carbenoxolone.
MECHANISM OF ACTION
Spironolactone acts on the distal renal tubules as a competitive antagonist of aldosterone. It increases the excretion of sodium chloride and water while conserving potassium and hydrogen ions.
Furosemide is used for the treatment of edema (water retention) due to disease of heart, liver or kidney. It can also be used for relieving symptoms in acute left ventricular heart failure (inefficient working of left side of heart).
Photosensitivity, Skin rashes, Ototoxicity, Nephrocalcinosis, Hyponatremia, Urinary retention, Dizziness, Blurred vision, Hypokalemia, Cardiac arrhythmias, CHO intolerance, Hypomagnesemia, Hyperosmolar non-ketotic precoma, deafness, Hypocalcemic tetany, Ototoxicity, Hypochloremic alkalosis.
Furosemide is known to interact with other drugs like Aliskiren, Amikacin (Sulphate), Arbekacin, Caffeine, Calcium Gluconate, Captopril, Carbamazepine, Cefaclor (Monohydrate), Cefazolin, Cefotaxime, Ceftizoxime (Na).
MECHANISM OF ACTION
Furosemide inhibits reabsorption of Na and chloride mainly in the medullary portion of the ascending Loop of Henle. Excretion of potassium and ammonia is also increased while uric acid excretion is reduced. It increases plasma-renin levels and secondary hyperaldosteronism may result.
Can I take Amifru S during pregnancy?
Experiences of drug use and evidence from studies in pregnant women have shown risk to fetus. This drug may be used in pregnant women if benefit outweighs the risk. Patients should follow the advice of the doctor regarding its use.