SALT INFORMATIONAmpicillin + Cloxacillin(500mg)
Gram positve bacteria, H-influenzae, E-coli, Proteus, Salmonella and Shigella, Strep.viridans, pneumococci, gonococci and meningococci.Urinary tract infections. Respiratory tract infections. Meningitis. Gonorrhoea. Cholecystitis. Subacute bacterial endocarditis. Septicaemias and mixed infections.
Cholestatic jaundice, hemolytic anemia, blood dyscrasias, seizures, interstitial nephritis, cholestasis, neurotoxicity, rashes, fever, joint pain, eosinophilia, bronchial asthma, angioneuratic oedema, hemolytic anaemia, serum sickness.
Failure of oral contraceptives, increased rash with allopurinol, reduced bactericidal activity with chloramphenicol, erythromycin and tetracyclines.
MECHANISM OF ACTION
Ampicillin exerts bactericidal action on both gm+ve and gm-ve organisms. Its spectrum includes gm+ve organisms eg, S pneumoniae and other Streptococci, L monocytogenes and gm-ve bacteria eg, M catarrhalis, N gonorrhoea. Ampicillin exerts its action by inhibiting the synthesis of bacterial cell wall. Cloxacillin is a penicillinase-resistant penicillin. Cloxacillin by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is active against gm+ve organisms including penicillinase-producing strains of Staphylococci. Cloxacillin is highly active against Staph aureus, Strep pyogenes, Strep viridans and Strep pneumoniae. It is also active against penicillinase-producing gonococci and against N meningitidis and H influenzae.
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Can I take Ampoxin (500mg) during pregnancy?
Studies in animals have shown no risk to the fetus, however there are no sufficient studies in humans. Patients should follow the advice of the doctor regarding its use. Patients should follow the advice of the doctor regarding its use.